Blue Collar Brain & Focus Formula

Formula Ingredient DeckBenefits Of Each Ingredient Vitamin A

• Supports vision health, skin health, immune health, and increases antioxidant support (182, 183). Supports antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased l-glutathione production (master antioxidant) (182,183).

• Supports visual health via increased amounts of plasma vitamin A in macular (eye) tissues (182,183).

Vitamin C

• Supports immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).

• Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).

• Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).

• Supports accelerate bone healing after a fracture, increase type I collagen synthesis, and reduce oxidative stress (inflammation) (98).

Vitamin D

• Supports exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance, strength, and positive mood (77,78,79).

• Supports hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone-based negative feedback loop reactions (77,78).

• Supports cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77,78).

• Supports exercise performance via reduced exercise-associated inflammation and muscle damage (77,78).

• Supports sexual health via increased activity of Vitamin D receptor activity of testosterone production (79).

• Supports immune function via decreases of inflammatory cytokines and aiding immune cells (77,78).

• Supports joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77,78).

Vitamin E

• Supports immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208)

• Supports immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204).

• Supports cardiovascular health via reduced cholesterol (204).

• Supports cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208).

Vitamin B1 (Thiamine)

• Supports aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).

• Supports cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95).

Vitamin B2 (Riboflavin)

• Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93).

Vitamin B3 (Niacin)

• Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).

• Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).

• Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).

• Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).

• Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11).

• Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12).

• Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9).

• Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9).

• Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).

Vitamin B6

• Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).

• Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).

• Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).

• May support blood sugar regulation in women with gestational diabetes (40).

• Cofactor for enzymes involved in DNA metabolism (40).

Folic Acid

• May support proper cell growth and DNA synthesis (65).

Biotin

• Supports conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214).

• Enhances glucose breakdown into skeletal muscle tissue (213,214).

Vitamin B5

• Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).

Calcium

• Supports bone health, muscle function, and cardiovascular health (36,37).

• Regulates processes of bone resorption, mineralization, and fracture repair (36,37).

• Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).

• Prevents the development of preeclampsia (36,37).

Iron

• Supports red blood cell formation, immune function, and antioxidant support (215,216).

• May increases oxygen uptake into red blood cells of Iron deficient individuals (215,216).

• May support gut health of iron-deficient individuals.

• Combats anemia in Iron deficient individuals (217).

Magnesium

• Supports optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91).

• Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91).

• Supports reduction systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91).

• Reduces peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91).

Zinc

• Supports immune function, skin health, cognitive function, and vision (172,173).

• Supports stimulation of the innate and adaptive immune system (172,173).

• Supports the activation of lymphocytes and activation of innate and T cell-mediated immunity (172,173).

• Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173).

Selenium

• Supports antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146).

• Combats atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147).

• Supports thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146).

• Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increase natural killer activity, and increases glutathione (master antioxidant) levels (145,147).

Copper

• Supports healthy blood sugar levels, energy metabolism and cholesterol management (143,144).

Manganese

• Supports enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148,149).

Chromium

• Supports insulin function, reduced cholesterol, improved blood sugar regulation, and may lower cholesterol (218,219).

Molybdenum

• Increases enzymatic reactions involved in sulfite metabolism and detoxification (150).

DMAE Bitartrate

• Increases acetylcholine levels in the brain.

L-Glutamine

• The most abundant amino acid in skeletal muscle that fuels immune cells, improves exercise recovery, and optimizes gut microbiome (18).

• Vital for lymphocyte (immune cell) proliferation (growth) and paramount in neutrophil (immune cell) destruction of bacteria (18).

• Vital for activation of genetic signals that support immune function and vitality (18).

• Glutamine is utilized by immune cells at high rates during catabolic conditions (post-surgery, sepsis, burns, and extreme exercise (18).

Glutamic Acid

• Supports cognitive function and focus (220).

Green Tea Extract

• A potent polyphenolic antioxidant that supports blood pressure, insulin sensitivity, and metabolic health (26).

• High in ECGC (epigallocatechin gallate) (26).

• ECGC is shown to reduce body fat mass, increase fat oxidation(burning) and increase caloric expenditure during exercise (25).

• Potent anti-inflammatory compound supporting glutathione production and inhibition of pro-inflammatory markers (cytokines) (26).

• Reduces oxidative stress (chronic inflammation in the body) (26).

Choline

• Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63).

• Serves as a methyl donor and as a precursor for the production of cell membranes (62).

• Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64).

• Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62).

• Reduces the concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62).

Inositol

• Supports liver detoxification, combats metabolic syndrome, and aids as an antioxidant (221).

• Combats metabolic syndrome via reduced levels of triglycerides, total- and LDL-cholesterol (221).

• Supports antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222).

N-Acetyl Tyrosine

• Supports memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60).

• The precursor to dopamine and is vital for dopamine synthesis in the brain (60).

• Supports cognitive function in individuals with high amounts of stress and anxiety (60,61).

• Increases dopamine levels in highly stressed individuals (60).

Bilberry Fruit

• Supports vision health, cardiovascular function, increased nitric oxide production, and antioxidant support (223,224).

Grape Seed Extract

• Supports increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31).

• Supports antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31).

• Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

Olive Leaf

• Supports cardiovascular health, antioxidant function, and controlled blood sugar levels (224).

• Supports Cardiovascular health via reduction of systolic BP, LDL, and inflammatory biomarkers (224).

• Supports antioxidant function via anti-inflammatory polyphenols that protect against DNA damage initiated by free radicals (225).

• Combats major inflammatory pathways via anti-inflammatory change involving inflammation pathway (NF-κB inhibition) (225).

• Supports blood sugar regulation via improved insulin sensitivity and pancreatic β-cell (cells responsible for secreting insulin) secretory capacity (226).

Licorice Root

• Supports anti-inflammatory, anti-allergenic, and antimicrobial properties (177).

Boron

• Supports increased bone mineral density, muscle function, hormonal balance, and immune function (180).

DHA (Fish Oil)

• Vital for optimal cardiovascular, hormonal, immune, cognitive, digestive health, and recovery from exercise (73,74,76).

• Fish oil consumption of 6 grams per day has been shown to reduce inflammation, reduce muscle soreness, and reduced the perception of pain in exercising individuals (76).

• Increases skeletal muscle hypertrophy than individuals consuming only whey protein post-exercise (76).

• Supports cardiovascular health by decreasing atrial fibrillation, atherosclerosis (plaque buildup), thrombosis, blood pressure, and supporting blood lipid profiles (cholesterol panel) (73,74,75).

• Lowers blood pressure via increased production nitric oxide production and induced endothelial relaxation (75).

• Supports healthy information by decreasing c-reactive protein (inflammatory markers) in the body and increasing insulin sensitivity (75,76).

• Supports cognitive health by increasing the concentration of omega 3 fatty acids in the cell membranes of the cerebral cortex and synaptic vesicles (76).

Vanadyl Sulfate

• Supports blood sugar regulation via improved insulin sensitivity and pancreatic beta-cell function (cells that produce insulin) (227).

Phosphatidylserine

• Supports cognitive function, memory, and focus, and reduced stress (228,229).

• Reduces prevalence of short-term memory loss in ADHD patients improved prefrontal cortex (PFC) pyramidal cells function (228).

• Increases dopamine and acetylcholine release via maintenance of acetylcholine supply (228).

• Reduces cortisol levels in the frontal Brian regions during stressful activity (228,229).

Huperzine A

• Supports cognitive function, memory, focus, and combats neurodegenerative disease (230).

• Combats neurodegenerative disease via improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease (230).

• Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways. Molecular aspects of medicine, 53, 10–27. https://doi.org/10.1016/j.mam.2016.08.001

• Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in food and nutrition research, 83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004

• Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., & Raiten, D. J. (2015). Biomarkers of Nutrition for Development-Folate Review. The Journal of nutrition, 145(7), 1636S–1680S. https://doi.org/10.3945/jn.114.206599

• Thakur, K., Tomar, S. K., Singh, A. K., Mandal, S., & Arora, S. (2017). Riboflavin and health: A review of recent human research. Critical reviews in food science and nutrition, 57(17), 3650–3660. https://doi.org/10.1080/10408398.2016.1145104

• Suwannasom, N., Kao, I., Pruß, A., Georgieva, R., & Bäumler, H. (2020). Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. International journal of molecular sciences, 21(3), 950. https://doi.org/10.3390/ijms21030950

• DiNicolantonio, J. J., Niazi, A. K., Lavie, C. J., O'Keefe, J. H., & Ventura, H. O. (2013). Thiamine supplementation for the treatment of heart failure: a review of the literature. Congestive heart failure (Greenwich, Conn.), 19(4), 214–222. https://doi.org/10.1111/chf.12037

• Saedisomeolia, A., & Ashoori, M. (2018).Thiamine in Human Health: A Review of Current Evidences. Advances in food and nutrition research, 83, 57–81. https://doi.org/10.1016/bs.afnr.2017.11.002

• Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211

• DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic journal of sports medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544

• Eggersdorfer, M., & Wyss, A. (2018). Carotenoids in human nutrition and health. Archives of biochemistry and biophysics, 652, 18–26. https://doi.org/10.1016/j.abb.2018.06.001

• Sunkara, A., & Raizner, A. (2019). Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment. Methodist DeBakey cardiovascular journal, 15(3), 179–184. https://doi.org/10.14797/mdcj-15-3-179

• Age-Related Eye Disease Study Research Group (2001). A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Archives of ophthalmology (Chicago, Ill. : 1960), 119(10), 1417–1436. https://doi.org/10.1001/archopht.119.10.1417

• Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020). Could Vitamins Help in the Fight Against COVID-19?. Nutrients, 12(9), 2550. https://doi.org/10.3390/nu12092550

• Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free radical biology & medicine, 43(1), 4–15. https://doi.org/10.1016/j.freeradbiomed.2007.03.024

• Wu, D., & Meydani, S. N. (2014). Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocrine, metabolic & immune disorders drug targets, 14(4), 283–289. https://doi.org/10.2174/1871530314666140922143950

• De la Fuente, M., Hernanz, A., Guayerbas, N., Victor, V. M., & Arnalich, F. (2008). Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research, 42(3), 272–280. https://doi.org/10.1080/10715760801898838

• Browne, D., McGuinness, B., Woodside, J. V., & McKay, G. J. (2019). Vitamin E and Alzheimer's disease: what do we know so far?. Clinical interventions in aging, 14, 1303–1317. https://doi.org/10.2147/CIA.S186760

• Mock DM. Biotin: From Nutrition to Therapeutics. J Nutr. 2017 Aug;147(8):1487-1492. doi: 10.3945/jn.116.238956. Epub 2017 Jul 12. PMID: 28701385; PMCID: PMC5525106.

• Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017 Aug;3(3):166-169. doi: 10.1159/000462981. Epub 2017 Apr 27. PMID: 28879195; PMCID: PMC5582478.

• Cappellini, M. D., Musallam, K. M., & Taher, A. T. (2020). Iron deficiency anaemia revisited. Journal of internal medicine, 287(2), 153–170. https://doi.org/10.1111/joim.13004

• Paganini, D., & Zimmermann, M. B. (2017). The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: a review. The American journal of clinical nutrition, 106(Suppl 6), 1688S–1693S. https://doi.org/10.3945/ajcn.117.156067

• Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003). Bacterial iron homeostasis. FEMS microbiology reviews, 27(2-3), 215–237. https://doi.org/10.1016/S0168-6445(03)00055-X

Serving Size: 2 Capsules; Capsules Per Container: 60; Bottle Color: White; Bottle Size: 175cc; Lid Color: White

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.